生命科學學院學術預告


發布日期:2020-01-03訪問次數: 字號:

1、報告題目:Bioproduction in the algal chloroplast

時間:2020年16日周一 上午8:30

地點:河北農業大學西校區生命科學學院二樓報告廳

報告人:Prof. Saul Purton,Department of Structural & Molecular Biology, University College London

       報告摘要:Microalgae have significant potential as light-driven cell factories for the synthesis of a wide range of bioproducts. These include bioactive metabolites, high-value pigments, speciality enzymes, therapeutic proteins, biopolymers and RNA-based anti-viral agents. The genetic engineering of algae is most advanced for the model species Chlamydomonas reinhardtii, with well-established methods for manipulating both the nuclear and chloroplast genomes. The latter is particularly attractive as a site for insertion of foreign genes for a number of reasons: i) genes can be targeted to precise loci; ii) stable, high level expression can be achieved; iii) the small, low complexity genome is particularly suited to synthetic biology (synbio) approaches that allow rapid, standardised and predictive strain engineering; iv) the organelle is the site of numerous biosynthetic pathways and therefore represents the obvious ‘chassis on which to bolt new metabolic pathways that divert the carbon fixed by photosynthesis into novel compounds. I will present our recent progress on the development of synbio tools for genetic engineering of the chloroplast of C. reinhardtii, including a simple one-pot method for DNA assembly and selection methods that avoid the use of antibiotic-based markers. Our tools also include design strategies for biocontainment of transgenes, and their high-level and inducible expression, together with a method for low-cost algal cultivation in non-sterilised media. I will give examples of applications in the field of therapeutic proteins including the production of anti-bacterial enzymes that target major human pathogens, and bio-encapsulated vaccines for oral delivery in the aquaculture industry.


1、報告題目:微藻甘油三酯和高值產物的生物合成及應用啟示

時間:2020年16日周一 上午10:00

地點:河北農業大學西校區生命科學學院二樓報告廳

報告人:劉進 研究員

       劉進,博士,北京大學工學院研究員,能源與資源工程系PI,食品與生物資源工程研究所PI2003年和2005年于中山大學分別獲得理學學士和理學碩士學位,2010年于香港大學獲得理學博士學位。隨后分別于美國Arizona State UniversityUniversity of Maryland從事博士后和助理研究員工作。2015年加入北京大學工學院,擔任微藻生物技術創新課題組負責人,致力于通過交叉學科前沿科學技術開展藻類資源的基礎及應用研究。曾入選國家青年千人計劃、博雅青年學者等。目前已在SCI知名期刊(Molecular Plant, Plant Journal, Biotechnology for Biofuels, Metabolic Engineering, Food Chemistry, Applied Microbiology and Biotechnology等)上發表學術論文50多篇(其中2篇為封面文章),ElsevierWiley-Blackwell等國際知名出版社發表專著章節8篇,主編專著1部,主持國家重點研發計劃課題、自然科學基金面上項目等多項項目。主要研究興趣:油脂代謝、類胡蘿卜素生物發生、藻類合成生物學。

 

作者:生命科學學院 編輯:宣傳部





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